Synopsis

Follows the surreal adventures of a cow, named Cow, and her chicken brother, named Chicken. They are often antagonized by "The Red Guy", who poses as various characters to scam them.

David Feiss first created Cow and Chicken as a story for his daughter.

Feiss was an animator who had worked with Hanna-Barbera and related projects since 1978.

Cow and Chicken premiered on What a Cartoon! in 1995.

The series focuses on the misadventures of two unlikely yet somehow biological anthropomorphic animal siblings: the sweet-natured, dim, ditzy, naive, and ecstatic 7-year-old Cow and her older 11-year-old brother, the hot-tempered, cynical, and sarcastic Chicken (both voiced by Charlie Adler).

Supporting characters include Chicken and Cow's delirious human parents Dad and Mom (Dee Bradley Baker and Candi Milo, respectively), only seen from the waist down and implied to have no torsos, heads, or arms; Chicken's best friends Flem (Howard Morris) and Earl (Dan Castellaneta); and their cousin, Boneless Chicken (Adler).

The humor and storylines depicted are usually based on traditional childhood worries, anxieties, or phobias such as cooties or venturing into the girls' restroom, but enhanced comically.