Foster's Home for Imaginary Friends

Sean Marquette was cast as Mac, and Keith Ferguson was cast as Bloo.

The Powerpuff Girls voice actors Tom Kane, Tom Kenny and Tara Strong were cast in Foster's as Mr.

Grey DeLisle was cast as Frankie Foster, Phil LaMarr was cast as Wilt, and Candi Milo was cast as Coco and Madame Foster.

Most of the episodes were produced and animated at Cartoon Network Studios in Burbank, California, while the rest were animated at Boulder Media Limited in Dublin, Ireland.

Venable, who had originally collaborated with McCracken on The Powerpuff Girls.

Collette Sunderman was the casting and recording director for the show.